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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Tubeimoside I, TNF-related apoptosis inducing ligand
Phytochemical Name Tubeimoside I (PubChem CID: 6110917 )
Anticancer drug Name TNF-related apoptosis inducing ligand (PubChem CID: / )
Structure of
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2D MOL 3D MOL
Structure of
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 1032
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Pair Name Tubeimoside I, TNF-related apoptosis inducing ligand
Disease Info [ICD-11: 2A00-2F9Z] Solid tumour or cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression STAMBPL1 hsa57559
Down-regulation Expression CFLAR hsa8837
In Vitro Model Caki-1 Clear cell renal cell carcinoma Homo sapiens (Human) CVCL_0234
A-549 Lung adenocarcinoma Homo sapiens (Human) CVCL_0023
HeLa Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_0030
HCT 116 Colon carcinoma Homo sapiens (Human) CVCL_0291
In Vivo Model Male SCID mice were inoculated subcutaneously at the flank with HCT116 (5×10⁶) cells.
Result Our study revealed that STAMBPL1 is essential for c-FLIP stabilization, and that STAMBPL1 depletion enhances TRAIL-mediated apoptosis via c-FLIP downregulation.
03. Reference
No. Title Href
1 Tubeimoside-1 Enhances TRAIL-Induced Apoptotic Cell Death through STAMBPL1-Mediated c-FLIP Downregulation. Int J Mol Sci. 2023 Jul 24;24(14):11840. doi: 10.3390/ijms241411840. Click
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